lads i was really just going about my life today and i came into my genetics lecture and my professor put both hands on the podium and explained to our suddenly silent 200+ person lecture hall that a chinese scientist has just created the world’s first GMO babies by taking human embryos and modifying them to be resistant to HIV. there are two of them and they’re twins. apparently we don’t know yet if it’s successful but it was at a conference where a ton of GMO researchers were discussing if genetic modification of humans should be allowed and if so to what extent and apparently this dude got the microphone and said ‘ive already done it’ and showed some data (apparently not a lot though) and there’s a ton of drama happening right now because ‘what the FUCK do you MEAN you already did it????? what the FUCK dude?????’. my professor kept saying to us with complete sincerity ‘this is important, this is really, really important’ and anyway i just…….what a time to be alive, you know?
like i dont feel comfortable taking a stance on any of this without more information but i do know for certain that god, i wish i could have witnessed that room of GMO researchers when this dude got the mic and was really like ‘i have modified human embryos’
more info provided to me by @sunsetsovercitylights:
Hey! I’m a scientist who works with gene editing and can def give you more context on the gmo babies! tldr it’s unethical and Not Great, but basically there’s been an (unenforceable) international moratorium on gene editing humans since 2015. It’s maybe illegal, maybe just advised against in China. The university, hospital, and government are all denying knowledge of it tho, which makes this super shady. (1/?)
Here’s the thing: gene editing has been used in therapy in humans, but 1. patients give full consent and 2. cells are removed from the body, CHECKED, double-checked, then put back in, because gene editing can have off-target effects and we want to avoid those, and 3. only cells that can’t be inherited are edited, so that an individual is only giving consent to alter their own body, not their children and/or the general gene population. NONE OF THOSE THREE HAPPENED IN THIS CASE. (2/?)
It’s extremely unclear if the parents knew what was happening, other than that the dad was HIV+ and the research was supposed to prevent the kids from getting HIV. (There are a LOT of cheaper and more accessible ways to do this than gene editing). So far, the scientist hasn’t proven that he checked for (or prevented) off target effects – but we do know one of the kids is a mosaic, meaning only SOME of her cells were altered. This could be really bad for her health, we literally don’t know (3/?)
This guy waited until he had produced human beings to make his announcement, didn’t consult the public, other scientists, or regulatory boards, and sprung the announcement RIGHT before the human gene editing conference – which signals that he did this for his own sake, not for science. He’s set a dangerous precedent and potentially damaged the public perception of gene editing, not to mention endangering those children (the edit made them more susceptible to West Nile). So. Fuck that guy. (4/4)
this is…quite literally the wildest shit like i understand the incredible temptation to try something just to see if it could be done, every scientist understands that, but holy shit dude what the fuck?
idk this has a LOT happening and im not gonna be able to address all of it but my thoughts right off the bat: current gene editing (see: modifying someone’s existing genome. different from this case because in gene editing, the person is born and is displaying symptoms of a genetic disease, where here the embryos are being modified before birth) is pretty life changing and very safe and effective from my understanding of it and what i’ve been taught, and it makes me angrier knowing that this might set back that kind of science that’s more ethical in terms of consent. i also don’t like that the lives of these kids are gonna be inherently controversial. i also don’t like……………uh…..almost all of this, actually. like this is A Lot, holy shit.
Have I watched the movie in the last decade or more? No.
Do I have iron clad evidence to support my argument? Yes.
1. She’s the most knowledgeable about candy. She’s committed to it, and knows her stuff. When Wonka holds up a little yellow piece across the room, she recognizes it immediately. She was able to switch to candy bars for the sake of the contest, so we know she has personal discipline and is goal oriented. Also, two major projects play directly into her strong suits: the 3-course-meal gum that Wonka failed to make safe (gum) and the neverending gobstopper (longevity).
2. She’s the most fit to run a business. Violet is competitive, determined, hard working, and willing to take risks. Her father is a small town car salesman and politician, so she could easily pick up knowledge and support from him. (Veruca’s dad is also a business man, and in a compatible market (nuts), but it’s made very clear that Veruca has no respect or knowledge of business practices or hard work.)
3. She’s the most sympathetic to the Oompa Loompas. She critiques Veruca when Veruca demands to buy one. More importantly, Wonka has been testing the 3-course-meal gum that ‘always goes wrong’ on Oompa Loompas while he presumably just watches. Violet is ready to put herself on the front line, instead of treating the Oompa Loompas as disposable, and would therefore be a better boss.
4. Her personality ‘flaw’ is the most fitting for the company. In the moralizing Oompa Loompa song, they just say ‘gum is pretty cool, but it’s not socially acceptable to chew it all day‘. The thing is, we already know that she can stop if she wants, because she already did that to win the golden ticket. And yeah, she is defensive about the perceived impoliteness of her hobby (like when her mother tries to shame her about her habit during a televised interview) but the obsession with candy and neglect of social norms is EXACTLY what Wonka is all about. This is on brand.
5. Her misstep in the factory is reasonable. Wonka shows everyone a candy he’s very proud of. Violet is like “oh sick, that’s gum, my special interest.” Wonka then pulls a “WRONG! It’s amazing gum!” So in the very moments before she takes the gum Wonka has mislead her just to belittle her. So when he’s like “I wouldn’t do that” why should she give a shit what he has to say? She’s not like Charlie over here who’s all “Sure Gramps, let’s stay behind while the tour leaves and secretly drink this thing that has been explicitly stated to fill you with gas and is too powerful for safe consumption, oh and also I just saw what happened to Violet so I actually KNOW what this stuff can be capable of” Also, Violet is not selfish about her experience, she tells everyone what she’s tasting and feeling, and everyone is eager to hear it. Taking a personal risk to share knowledge with everyone. Violet is Prometheus: fact.
So Augustus contaminates the chocolate river. Charlie sneaks around and contaminates the vent walls. Veruca destroys and disrupts the workspace. Mike knows exactly what will happen to him and transports/shrinks himself deliberately. Violet had no idea what the gum could potentially do to her, and caused no harm to anyone or anything but herself.
Lastly: Can you imagine Charlie filling Wonka’s shoes? That passive, naive boy? Violet is already basically Wonka. She’s passionate, sarcastic, candy-obsessed, free thinking, and a total firecracker. She’s even better than Wonka, because she doesn’t endanger others.
Violet should’ve been picked to inherit the chocolate factory.
It’s wild how like… JKR is so skilled at so many aspects of writing, especially in little character moments, but when it comes to implications of throwaway lines she just… not a SINGLE thought.
Like in Chamber of Secrets, when Harry is talking to Tom / Voldemort and is like, you Framed Hagrid, Tom is like, yeah he was always trying to raise monsters,
he says that Hagrid tried to raise werewolf cubs under his bed like…
oh you mean like, children? like human children?
broke: taako and lup explaining memes to a confused merle
woke: merle explaining memes to a confused, and horrified, John Hunger
ascendant: taako and lup explaining memes to merle, who then based on his understanding explains them to john, the information getting progressively less accurate along the line